💀 Fosamax, Boniva & Bone Loss — What You’re Not Being Told Someone asked me about once-weekly alendronate (Fosamax/Boniva) and whether it’s worth taking for years. Here’s the truth: These meds are bisphosphonates, and long-term they’ve been linked to osteonecrosis — permanent bone death. You take it to protect bone, but over time it may damage bone. That’s a problem. And despite decades of “take your calcium vitamin D,” I’ve never seen anyone reverse osteoporosis doing that. Not once. Because b
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Fosamax has six acidic groups. The structure of the active form of the drug is shown in the box. (Notice that the phosphorus atom in Fosamax and the sulfur atom in Problem 30 can be surrounded by more than eight electrons since P and S are below the second row of the periodic table.) a. The OH groups bonded to phosphorus are the strongest acids of the six groups. Why? b. Which of the remaining four groups is the weakest acid? | Numerade
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