The 49ers head to Houston for a defensive showdown versus the Texans. DeMeco Ryans' defense faces off against his former team, and head coach Kyle Shanahan's offense.

A week after the San Francisco 49ers improbably dominated the NFL's second-ranked offense, they'll be given a far less ...

Purdy last spoke to the media on Sept. 30, although he did have a conversation with NBC sideline reporter Melissa Stark when ...

49ers 24, Texans 16: San Francisco may be without defensive pillars Nick Bosa and Fred Warner, but the Houston offense has ...

If the 49ers win Sunday in Houston, they’ll match their overall win total from last season and they’ll be alone atop the NFC ...

HOUSTON -- After a 2-4 start, the Texans have a tough three-game home stretch ahead that could define their season.

The San Francisco 49ers take on the Houston Texans at 10 a.m. PT on Sunday, Oct. 26 at NRG Stadium in Houston.

Those who were declared out Sunday were quarterback Brock Purdy (toe), center Jake Brendel (hamstring), edge rusher Bryce ...

While the San Francisco 49ers have gained an early edge with victories against fellow 5-2 rivals Los Angeles and Seattle, right tackle Colton McKivitz knows a Week 8 visit to Houston offers a unique ...

HOUSTON – Derek Stingley Jr. lined up across from Seattle Seahawks star wide receiver Jaxon Smith just four times Monday ...

San Francisco 49ers head coach Kyle Shanahan detailed the team's latest injury report, opened up about his pregame speeches, ...

Specifically, there is one area on the Texans' defense that the 49ers will find the most challenging.Texans will challenge ...