In the three years since Christina Applegate was diagnosed with multiple sclerosis, the actress’ medical condition has steadily progressed. During a recent episode of her podcast MeSsy — co-hosted with Jamie-Lynn Sigler, who also received a MS diagnosis — she detailed the chronic pain she faces and how it impacts her daily life.

Christina Applegate is opening up about the pain she experiences from multiple sclerosis. The "Married... with Children" alum, 52, shared her latest health update during the Nov. 5 episode of the "MeSsy" podcast she co-hosts with fellow actress Jamie-Lynn Sigler,

Christina Applegate will not suppress how difficult her battle with multiple sclerosis is. During the Monday, November 5, episode of her "MeSsy" podcast with Jamie-Lynn Sigler, who also has the medical condition,

"I can't even pick up my phone sometimes because now it's travelled into my hands, so I'll, like, try to go get my phone or get my remote to turn on the TV or sometimes, I can't even hold them. I can't open bottles now.

Christina Applegate has shared the horrific experiences she goes through living with multiple sclerosis (MS). The star was diagnosed with the condition following advice from fellow actor Selma Blair, who she confided in about strange symptoms she was experiencing.

Speaking with her co-host Jamie-Lynn Sigler, who also has MS, on the latest episode of their MeSsy podcast, Applegate said, “I lay in bed screaming, like, the sharp pains, the ache, the squeezing.”

She detailed the effect the autoimmune disease, “I can’t even pick up my phone sometimes…or get my remote…sometimes I can’t even hold them. I can’t open bottles now.”

Christina Applegate is opening up about what she deals with during her struggles with the condition multiple sclerosis.

In a candid discussion on her MeSsy podcast, Christina Applegate shares the painful realities of living with Multiple Sclerosis, including sharp pains and debilitating symptoms that impact her daily life.