eLife23h
The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida, United States; Division of Vascular Surgery & Endovascular Therapy, Department of Surgery, ...
eLife23h
Does bumblebee preference of continuous over interrupted strings in string-pulling tasks indicate means-end comprehension?
Bumblebees (Bombus terrestris) have been shown to engage in string-pulling behavior to access rewards. The objective of this study was to elucidate whether bumblebees display means-end comprehension ...
eLife1d
Computational tool can pinpoint causal relationships from complex biological data
Researchers have developed a computational tool that can pinpoint cause-and-effect relationships from large datasets of live-cell images, and illustrated its performance using a tumour-on-a-chip model ...
eLife1d
Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells
Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK ...
Opinion
eLife1dOpinion
Point of View: Teaching troubleshooting skills to graduate students
Pipettes and Problem Solving is an initiative that teaches some of the skills needed to figure out why an experiment is producing unexpected results.
eLife1d
A mathematical model for ketosis-prone diabetes suggests the existence of multiple pancreatic β-cell inactivation mechanisms
This theoretical study makes a useful contribution to our understanding of a subtype of type 2 diabetes – ketosis-prone diabetes mellitus (KPD) – with a potential impact on our broader understanding ...
eLife1d
The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes
In Type 1 diabetes (T1D), insulin-producing β-cells are killed by islet-infiltrating immune cells in a process called “insulitis”. T1D results in a critical requirement for exogenous insulin and ...
eLife1d
Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators
These cells deploy complex cytoskeletal rearrangements to recognize and eliminate potential threats 3. Even in the steady state, myeloid cells constantly survey their surroundings for potential ...
eLife1d
CausalXtract: a flexible pipeline to extract causal effects from live-cell time-lapse imaging data
Live-cell microscopy routinely provides massive amount of time-lapse images of complex cellular systems under various physiological or therapeutic conditions. However, this wealth of data remains ...
eLife1d
WNKs regulate mouse behavior and alter central nervous system glucose uptake and insulin signaling
Departments of Pharmacology, UT Southwestern Medical Center, Dallas, USA Departments of Peter O’Donnell Jr. Brain Institute and Psychiatry, UT Southwestern Medical Center, Dallas, USA Department of ...
eLife2d
Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation
For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.
eLife2d
Cryo-EM structure of the CBC-ALYREF complex
Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.