A machine-learning method predicts whether a genetic variant is pathogenic and affects certain human tissues. The ...

How the hydrolytic activity of mitochondrial ATP synthase is modulated during brown adipose tissue (BAT) thermogenesis ...

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

It is boomtime for metabolism and metabolomics research. One hundred years after Otto Warburg put metabolism at the core of ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...

FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during ...

The gut microbiota and its functional metabolites play crucial roles in the development of intestinal fibrosis in patients ...

Human papillomavirus (HPV) and hyperactivated YAP1 form a YAP1-HPV oncogenic alliance to drive the malignant transformation ...

Co-expressing NPY and its inhibitory receptor Y2 in excitatory hippocampal cells allows inhibitory autoregulation of ...

CaMKII activates the HRI/eIF2α signaling pathway and inhibits the proteotoxicity induced by proteasome inhibition through ...

Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...

Macrophages are important cellular reservoirs of chikungunya virus (CHIKV), but the viral and host determinants that ...