Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.

Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...

In this study, we investigated the neuronal activity of the dentate gyrus (DG) with electrophysiological and optical imaging tools during sleep-wake cycles. We found that the activity of major ...

In the DDM, noisy evidence is accumulated into a decision variable until reaching one of the two bounds, representing commitment to one of two choices (e.g., left or right). In general, the average ...

CUTS is a cryptic exon RNA biosensor enabling real-time detection of TDP-43 loss of splicing function. CUTS exhibits a significant linear relationship with TDP-43 loss. CUTS can deliver an ...

Interdepartmental Graduate Program in Dynamical Neuroscience, University of California, Santa Barbara Although grid cells are one of the most well studied functional classes of neurons in the ...

One year after forming this Committee, we’re inviting applications from researchers in the Global South to join for a term ...

Together, the findings suggested that 17α-estradiol extensively reshaped the cell populations, cellular communication, neuropeptide secretion, and neural synapse activity in aged hypothalamus, which ...

Three senior figures at the US National Institutes of Health explain why the agency remains committed to supporting basic science and research.

Nearly a thousand diverse adaptive mutants converge into a handful of groups for which fitness responds the same way to ...

In summary, these BLI data demonstrate that B. subtilis MinD is capable of binding membrane in both monomeric and dimeric form, while the presence of ATP in the binding pocket appears to affect both ...

A model with a mixture of three different decision strategies is developed to characterize several atypical behavioral patterns of individuals with depression and anxiety in an uncertain reward ...