Houston Texans wide receivers Nico Collins and Christian Kirk have missed two straight practices on Wednesday and Thursday.

C.J. Stroud and the Houston Texans must overcome yet another obstacle as they take on the San Francisco 49ers in Week 8.

The Texans ruled out two of their top wide receivers. Nico Collins (concussion) and Christian Kirk (hamstring) will not play. Neither player practiced this week. Kirk has played only three games this season. Collins was injured in the fourth quarter of Monday night’s loss to the Seahawks. The Texans also ruled out cornerback Alijah Huzzie (knee).

Texans are leaning on rookies Jaylin Noel and Jayden Higgins and Xavier Hutchinson with Nico Collins, Christian Kirk out

We're not far from the midway point of the 2025 NFL season, with another full slate of matchups set to kick off Thursday. At this point in the schedule, winning games isn't the only challenge; so is staying healthy.

Collins hit his head against the turf early in the fourth quarter. He was shown on the ESPN broadcast entering the sideline medical tent and subsequently heading to the locker room for further evaluation. Collins has four catches for 27 yards so far on Monday night.