Nervous system functions, from motion to perception to cognition, depend on the active zones of neural circuit connections ...

New research has shown how astrocytes and microglia communicate in response to changes in sensory input to remodel synapses.

Researchers at VIB-KU Leuven shed light on an unusual signaling pathway that orchestrates synaptic structure and function during brain development. Leuven, 20 May 2025 - Researchers from the lab led ...

Scientists show that specifying the timing pattern of neurostimulation -- impulses used to activate the brain's own electrical signaling mechanisms -- can rebalance the strength of synaptic ...

Synaptic transmission is an energy hog. It requires neurons to tap ATP reserves to respond to incoming signals. How do they pull this off, thousands to millions of times per day? A new study ...

Researchers at Johns Hopkins Medicine say they unexpectedly found new information about a protein's special role in getting brain cells to communicate at the right time and place in experiments with ...

Both presenilin-1 or the less-studied presenilin-2 can act as the catalytic subunit of γ-secretase, the enzyme responsible for churning out Aβ peptides. A new study, published November 29 in Nature ...

Abstract: Neural tissue requires a great metabolic demand despite negligible intrinsic energy stores. As a result, the central nervous system (CNS) depends upon a continuous influx of metabolic ...

Increased levels of bioactive lipids produced naturally in the body, which affect excitatory transmission between brain cells, promote mental disorders. However, this mechanism can be rebalanced by ...

The rapid influx of cerebral spinal fluid (CSF) and protein solutes released during cortical spreading depression (CSD) in the brain activates neurons to trigger aural migraine headaches, according to ...