Late in the fourth quarter, first-round pick defensive end Mykel Williams went down with a right knee injury. Afterwards, coach Kyle Shanahan told reporters that they fear Williams injured his ACL. A torn ACL would sideline Williams for the remainder of the season.

NFL.com says teams are calling on Jauan Jennings, but with Aiyuk still ramping up and Shanahan signaling stability, a 49ers trade is unlikely.

So what’s it going to be this week with the New York Giants, who host the San Francisco 49ers? Will we see the team that held its own against the Los Angeles Ch

The San Francisco 49ers will have to wait at least another week before their starting quarterback is in uniform.

Mac Jones delivered another strong performance for the 49ers, but his final move of the game showed his true character.

Sunday in Week 9. Kickoff from MetLife Stadium in East Rutherford, New Jersey, is at 1 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Giants odds and make our expert NFL picks and predictions for the best bets.

The New York Giants play host to the San Francisco 49ers on Sunday in a battle of teams missing multiple star players on both sides of the ball.

The 49ers improved to 6–3, beating the Giants 34–24 in Week 9 behind Christian McCaffrey’s record-breaking performance.