The Detroit Lions loss to the Pittsburgh Steelers on Sunday secured San Francisco's place in the NFC playoff field with three games remaining in the regular season. The result, paired with the 49ers Week 15 win over the Tennessee Titans at Levi's® Stadium, locked in another postseason appearance for San Francisco.

Matt Maiocco identifies five 49ers players to watch in San Francisco's Week 16 game against the Indianapolis Colts.

In Week 15 against the Tennessee Titans, the 49ers surrendered 14 points in the fourth quarter. In Week 11 against the Arizona Cardinals, they allowed 12 points in the final quarter. Against the New York Giants, San Francisco again gave up 14 fourth-quarter points but responded by scoring the same amount to secure the win.

To clinch a playoff spot the 49ers needed the Pittsburgh Steelers to beat the Detroit Lions at Ford Field on Sunday. The seven-point underdog Steelers did San Francisco a favor by upsetting the Lions 29-24 while the 49ers sat in Indianapolis awaiting their Monday night showdown with the Indianapolis Colts.

The San Francisco 49ers and Indianapolis Colts meet for Monday Night Football at Lucas Oil Stadium in Indianapolis, Indiana. Kickoff is at 8:15 ET.

The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to watch, stream and NFL TV schedule.

The San Francisco 49ers got what they needed with the Seattle Seahawks win in Week 16, but one of their players learned a key lesson on a wacky play.

The 49ers (10-4) face NFL rushing leader Jonathan Taylor and unretired QB Philip Rivers on Monday night in Indianapolis against the Colts (8-6).

The Indianapolis Colts and San Francisco 49ers MNF tilt is regarded as one of the important games left in the season.

The San Francisco 49ers won't play until Monday night in Week 16, but other games on Sunday could impact their ideal finish to the season.