Amides and thioesters are ubiquitous compounds in chemistry, used for the production of medicines, natural products, and advanced materials. Traditionally, their synthesis is a messy business, ...

Researchers at the Biocatalysis group led by Dr Francesco Mutti at the Van ‘t Hoff Institute for Molecular Sciences (University of Amsterdam) have ...

The following protocol describes the selective cross-coupling of an amine with an aryl halide using a Pd-based catalyst to provide the corresponding N-arylated amine. This general procedure for C–N ...

Primary amines are extensively used in the manufacture of pharmaceuticals, agrochemicals, and material science. Among various reported methods to ...

It’s hard to improve on a classic. But Richard Y. Liu was eager to take on that challenge. Cross-coupling reactions, including Suzuki-Miyaura coupling and Buchwald-Hartwig amination, are some of the ...

A University of Illinois at Urbana-Champaign research team has discovered a way to produce a special class of molecule that could open the door for new drugs to treat currently untreatable diseases.