Genes are expressed when messenger RNA is made from DNA, which is then translated into proteins. Researchers use single-cell and bulk RNA-seq analysis to study gene expression, creating vast amounts ...

While widely adopted for comprehensive transcriptome profiling, the methods of poly-A selected or ribodepleted RNA-sequencing may have key limitations, including input mass requirements, inefficient ...

Cellular homeostasis and stress response are tightly coordinated processes involving a complex interplay between signaling ...

The enzyme RNA polymerase (RNAP) carries out transcription, copying DNA into RNA. It's the first step in gene expression, and a process fundamental to all life. But the inner workings of this ...

This article and associated images are based on a poster originally authored by Marisa Amato and presented at ELRIG Drug Discovery 2025 in affiliation with Singleron Biotechnologies GmbH. This poster ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut ...

Germline non-BRCA1/2 mutations and clinico-radio-pathologic features of early-onset breast cancer patients in Thailand. Genetic counseling (GC) in the era of next generation sequencing (NGS) to ...

Reverse transcriptase selection can make or break your molecular biology experiments. From thermostability to fidelity, each feature impacts cDNA yield and accuracy. Understanding your RNA quality, ...

Omics technologies have enabled researchers to study the molecular functions of human tissues. But some tissues—like the brain—are harder to access than others. Because of the limited access to living ...

Why do brain disorders affect men and women differently? Researchers used RNA sequencing to identify 3,000 sex-biased genes in the human cortex linked to psychiatric risk.