Entering the matchup with the Bills, the Chiefs had put up good defensive performances against tight ends, surrendering just 36.5 yards per game against the position. On Sunday, they gave up 149, including explosive plays to tight ends on each of Buffalo’s first three scoring drives.

Buffalo Bills running back James Cook gains 14 yards to put him at 101 rushing yards in the game against the Chiefs, becoming the first player to gain 100 yards against the Chiefs defense since Baltim

CHARLOTTE, N.C. — James Cook ran for a career-high 216 yards and two touchdowns, Josh Allen accounted for three scores and the Buffalo Bills returned from their bye with a resounding 40-9 win over the Carolina Panthers on Sunday.

Both Matt Milano and Terrel Bernard were out, but the Bills still used plenty of three-linebacker sets with Shaq Thompson, Dorian Williams and Joe Andreessen getting the bulk of it. Cole Bishop was also part of the solid run defense and he led the Bills with seven tackles while Williams had six and Andresseen five.

Buffalo Bills running back James Cook scores on a 64-yard touchdown run against the Carolina Panthers during Week 8 of the 2025 NFL season.

Bills' James Cook knows who real heroes are after career-day vs. Panthers originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. Word has it that Buffalo Bills running back James Cook is still running in Carolina.

James Cook ran for a career-high 216 yards and two touchdowns, Josh Allen accounted for three scores and the Buffalo Bills returned from their bye with a resounding 40-9

James Cook had a dominant first quarter and now has put the ball in the box on his longest run of the season. Cook took a 64-yard run for a touchdown, putting the Bills up 12-3 midway through the second quarter. Matt Prater missed the extra point wide left to keep Buffalo ahead by only nine.