We recently reported on the use of the Ad5[E1-, E2b-] platform expressing the TAA carcnioembryoninc antigen (CEA) (Ad5[E1-, E2b-]-CEA) as an immunization and immunotherapeutic modality to induce TAA ...
A critical issue for E1-deleted adenoviral vectors manufactured from 293 cells is the emergence of replication-competent adenovirus (RCA). These contaminants arise through homologous recombination ...
Viral vectors are gaining increasing importance in various medical applications. Among the different types of viral vectors, adenoviral (Ad) vectors have been used for a long time and have now ...
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