Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that underpins a wide array of physiological processes. It activates multiple effector pathways, most notably protein kinase A ...
The second messenger cyclic di-AMP (c-di-AMP) plays a pivotal role in bacterial physiology by regulating osmolyte transport, potassium uptake, cell wall integrity and the overall stress response.
The activation of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is key for antitumor immunity. However, the development of STING agonist-based strategies in cancer ...
Patrick Burnett, MD, PhD, FAAD, chief medical officer of Arcutis Biotherapeutics, discusses the mechanism of action for roflumilast cream, the only phosphodiesterase-4 inhibitor approved by the FDA ...
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