A research team featuring bioinformaticians from the Moscow Institute of Physics and Technology (MIPT) has identified reliable markers of gene activity. The discovery has potential for future ...
Recombinant adeno-associated viral (AAV) vectors are among the most popular gene delivery systems for gene therapy. While AAV vectors were initially thought to be minimally immunogenic, innate and ...
Transposable elements (TEs) are sequences that replicate and move throughout genomes, and they can be silenced through methylation of cytosines at CpG dinucleotides. TE abundance contributes to genome ...
'CpG islands' are often associated with promoter regions. A CpG island has traditionally been defined as a 200 bp region of DNA with a G+C content over 50% and an observed/expected CpG ratio of 0.6 or ...
In our cells, genes associated with alternative cell fate have to be silenced. DNA methylation and H3K27me3 on the histone are two of the most prevalent chromatin modifications that control the ...
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