In Week 6, Malik Mustapha came back. The 49ers used Sigle in a platoon with Mustapha for two games, but once Mustapha took his role back over, there were no more snaps for Sigle. The 49ers move Ji’Ayir Brown into the starting lineup and slide Jason Pinnock into the nickel, making Sigle the fourth safety.

NFL.com says teams are calling on Jauan Jennings, but with Aiyuk still ramping up and Shanahan signaling stability, a 49ers trade is unlikely.

The San Francisco 49ers have now had three key players suffer season-ending injuries in their defensive front after Mykel Williams tore his ACL.

Giants vs. 49ers will broadcast nationally on CBS in Week 9 of the 2025 NFL season. Kevin Harlan and Trent Green will call the game from the booth at MetLife Stadium, with Melanie Collins reporting from the sidelines. Streaming options for the game include Paramount+ and Fubo , which offers a free trial to new subscribers.

The Pats are sending Keion White to the 49ers, veteran insider Jordan Schultz reports. Signed through 2026, White is on a second-round contract. This is a pick-swap agreement, according to NFL.com’s Tom Pelissero. New England will add a 2026 sixth round pick; San Francisco receives White and a 2026 seventh-rounder.

In Sporting News' Week 10 picks against the spread, Philadelphia and San Francisco getting massive wins for their NFC playoff hopes while the Steelers keep up with the Ravens in the AFC North.

The 49ers on Sunday scored 20 unanswered points after Dart and Co. got a touchdown on the opening drive. The Giants never got closer than 10 for the remainder of the game, as San Francisco scored touchdowns on its first two fourth-quarter drives, to go up 27-10 and then 34-17.

The San Francisco 49ers are more desperate for help at edge rusher than any other team in the NFL. With Nick Bosa, Mykel Williams, and Bryce Huff all sidelined for significant time, the team barely has enough defensive linemen to field a full unit.