Head Coach Kyle Shanahan and the Niners now control their fate in their pursuit of the NFC West crown and the top overall seed in the NFC. The scary part for the rest of the NFC is San Francisco is just now getting healthy having overcome a variety of injuries to key personnel on both sides of the ball.

The Indianapolis Colts are at home in Week 16 for a Monday Night matchup with the San Francisco 49ers. So who do the NFL experts have winning this game? Perhaps not technically a must-win for the Colts,

The NFL season continues in Week 15 when the San Francisco 49ers host the Tennessee Titans on Sunday. Start time, how to watch, stream and NFL TV schedule.

Matt Maiocco identifies five 49ers players to watch in San Francisco's Week 16 game against the Indianapolis Colts.

Colts coach Shane Steichen said DT DeForest Buckner will return from a neck injury and play vs the 49ers on Monday Night Football.

The Indianapolis Colts' latest injury update sparks concern for quarterback Philip Rivers ahead of the San Francisco 49ers game.

In Week 15 against the Tennessee Titans, the 49ers surrendered 14 points in the fourth quarter. In Week 11 against the Arizona Cardinals, they allowed 12 points in the final quarter. Against the New York Giants, San Francisco again gave up 14 fourth-quarter points but responded by scoring the same amount to secure the win.

San Francisco 49ers tight end George Kittle's wife, Claire Kittle, has partnered with Smirnoff to continue bringing the party to the team's home stadium suite.

San Francisco could suddenly be a dark-horse team to win the NFC West and get the conference's No. 1 overall seed.