Seattle is the best team in the NFC, as painful as that may be to read. They’re complete defensively, have a star wide receiver, an offensive line to protect Sam Darnold, and a bright head coach. But if Darnold has to go on the road in the playoffs, all bets are off.

Expert recap and game analysis of the San Francisco 49ers vs. Arizona Cardinals NFL game from September 21, 2025 on ESPN.

San Fransisco 49ers OC Klint Kubiak addressed the media on Thursday and discussed the injury status of QB Brock Purdy, offering a vague update.

The San Francisco 49ers and Arizona Cardinals are set to kick off on Sunday, and they'll be without a few players, who have been deemed inactive.

Following an unprecedented string of nail-biting defeats, the Cardinals ended their five-game losing streak with a Jacoby Brissett-fueled 27-17 win over the Dallas Cowboys, though Jonathan Gannon said Kyler Murray remains Arizona's starter when healthy.

At 2-5, the Arizona Cardinals face a tall and difficult task to turn things around, and, in predicting how it will end, it's too tall to conquer.

The Arizona Cardinals have beaten the Dallas Cowboys 27-17 at AT&T Stadium on “Monday Night Football,” ending their five-game losing streak. Jacoby Brissett, filling in for the injured Kyler Murray, threw for 261 yards and two touchdowns. Marvin Harrison Jr. had a career-high seven receptions for 96 yards and a TD.