INDIANAPOLIS — Pro Bowl defensive tackle DeForest Buckner was activated off injured reserve Monday and will play for the Indianapolis Colts in a crucial contest against the San Francisco 49ers. Buckner missed the previous five games with a neck injury.

The Indianapolis Colts continue to pile up losses one after another, and now on Monday Night Football against the San Francisco 49ers, another defeat would be the worst possible outcome, especially knowing they still have a small chance to reach the playoffs.

One San Francisco 49ers rookie could be in line for his NFL debut when the 49ers visit the Indianapolis Colts on Monday.