WASHINGTON—Centrist Sen. Thom Tillis (R., N.C.) said he won’t seek re-election in 2026, less than 24 hours after he voted against a motion to advance President Trump’s tax and spending megabill, drawing public backlash from the president.

Flake. Corker. Romney. And now, Sen. Thom Tillis. The roll call of Republican senators in the U.S. Congress who have called it quits, rather than endure a political career sideways with President Donald Trump,

North Carolina Republican U.S. Sen. Thom Tillis made an unexpected decision not to seek a third term. Here’s what the reaction has been.