The Lions vs 49ers produced the biggest audience to watch any Monday Night Football game in 2024. Over 22.2 million people tuned into the ESPN broadcast. It ranks as one of the top-five highest audiences for a Monday night game since 2006, when ESPN took over the long-running primetime football franchise.

The Detroit Lions got their revenge on the San Francisco 49ers. Here are winners and losers from the Week 17 Monday Night Football clash.

Newsweek Sports' expert predictions for Detroit Lions vs. San Francisco 49ers on Monday Night Football Week 17.

The Detroit Lions could have rested their starters on Monday night against the San Francisco 49ers with the knowledge that it's a Week 18 tilt with the Minnesota Vikings that will determine the NFC North and the conference's top seed. The San Francisco 49ers, already eliminated from playoff contention, could have also played out the string.

And don't be surprised if the Lions-Vikings winner-take-all finale smashes the Sunday Night Football high mark for this year, either.

SportsLine's NFL model locked in its Week 17 Monday Night Football NFL anytime TD picks for San Francisco vs. Detroit

The 49ers host the Lions as Detroit tries to keep pace for the NFC's top seed. Here's everything to know for "Monday Night Football" in Week 17.

It's the Detroit Lions vs San Francisco 49ers on Monady Night Football in Week 17 of the 2024 NFL season. Here's how to watch, including time, TV channel and streaming info.

Check out our Lions vs. 49ers how-to-watch guide to learn when they play and what free live streams are available ahead of kickoff.